Nobiletin as a Tyrosinase Inhibitor from the Peel of Citrus Fruit
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概要
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A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) by 'comparison with reported spectral data. Nobiletin (IC_<50> of; 46.2 μM) exhibited more potency than Kojic acid (IC_<50>; 77.4 μM) used as a positive control, and it was found to be potentially an effective inhibitor of the production of melanin.
- 公益社団法人日本薬学会の論文
- 2002-06-01
著者
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YOSHIZAKI Fumihiko
Tohoku Pharmaceutical University
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Yoshizaki Fumihiko
Tohoku College Of Pharmacy
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Sasaki Kenroh
Tohoku Pharmaceutical University
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