Influence of Coexisting Crude Drugs on the Inhibitory Activity of Sinomeni Caulis et Rhizoma on Mouse Plasma Alkaline Phosphatase

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概要

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• A hot water extract of Sinomeni Caulis et Rhizoma inhibited the mouse plasma alkaline phosphatase (ALP) activity. Sinomenine and other alkaloids in this crude drug were found as the active principles. In this work, to study the influence of coexisting crude drugs in Chinese medicinal prescriptions, a mixture of Sinomeni Caulis et Rhizoma and one of 28 crude drugs was extracted with hot water and the ALP inhibiting activities of the extracts were compared. Angelicae Radix, Astragali Radix, Atractylodis Lanceae Rhizoma, Glycyrrhizae Radix, Mori Cortex and Phytolaccae Radix augmented the activity of Sinomeni Caulis et Rhizoma. However, Angelicae Radix, Glycyrrhizae Radix, Mori Cortex and Phytolaccae Radix seemed to contain ALP inhibiting components. Phytolaccae Radix apparently enhanced the activity by increasing the rate of extraction of total alkaloids from Sinomeni Caulis et Rhizoma.

• 日本生薬学会の論文
• 1995-03-20

著者

• YOSHIZAKI Fumihiko

  Department of Pharmacognosy, Tohoku Pharmaceutical University

• Yoshizaki F

  Department Of Pharmacognosy Tohoku Pharmaceutical University

• Yoshizaki Fumihiko

  Tohoku College Of Pharmacy

• Suzuki Mie

  Tohoku College Of Pharmacy

• ANDO TOSHIO

  Tohoku College of Pharmacy

• HOUGA MASAMI

  Tohoku College of Pharmacy

• Suzuki M

  Kitasato Inst. Tokyo Jpn

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