Mutations of the Cardiac Ryanodine Recepter (RyR2) Gene in Catecholaminergic Polymorphic Ventricular Tachycardia
スポンサーリンク
概要
- 論文の詳細を見る
In 20 cases with clinically-diagnosed catecholaminergic polymorphic ventricular tachycardia (CPVT) from 12 unrelated Japanese families, we conducted genetic testing on RyR2, a gene encoding the cardiac ryanodine receptor. The correlation between RyR2-mutations and clinical phenotypes was investigated. The RyR2 mutations were found in 9 cases from the 20 probands (incidence: 45.0%) and in 3 from the 12 family members manifesting CPVT (incidence: 25.0%) Both bidirectional ventricular tachycardia (bVT) and atrial arrhythmias were significantly more frequent in RyR2-positive compared to RyR2-negative CPVT patients. The findings suggested that RyR2 mutations are closely related with bVT and atrial arrhythmias of early onset.
著者
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Sumitomo Naokata
Department Of Pediatrics And Child Health Nihon University School Of Medicine
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Nagaoka Iori
Department Of Cardiology Shiga University Of Medical Science
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Ishida Katsuya
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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Makiyama Takeru
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Kawamura Mihoko
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Horie Minoru
Department Of Cardiac Physiology National Cardiovascular Center Research Institute
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Mizusawa Yuka
Department Of Cardiology Tokyo Metropolitan Hiroo General Hospital
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Nishio Yukiko
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Sciences
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Ishida Katsuya
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Kimura Hiromi
Department Of Anesthesiology Kansai Medical University
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Itoh Hideki
Department Of Anesthesiology And Critical Care Medicine Yokohama City University Graduate School Of
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Miyamoto Akashi
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Ito Makoto
Department Of Bioscience And Biotechnology Graduate School Of Bioresource And Bioenvironmental Scien
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Oyama Kotaro
Department Of Pediatric Cardiology Iwate Medical University Memorial Heart Center
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Ohno Seiko
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Kimura Hiromi
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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MIZUSAWA Yuka
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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Dohchi Kenichi
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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Jito Yuko
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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Makiyama Takeru
Department of Cardiovascular Medicine, Kyoto Univercity Graduate School of Medicine
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SUMITOMO Naokata
Department of Pediateics and Child Health, Nihon University School of Medicine
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Nagaoka Iori
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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Ohno Seiko
Department of Cardiovascular Medicine, Kyoto Univercity Graduate School of Medicine
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ITO Makoto
Department of Bioresources, Faculty of Agriculture, Ehime University
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