Bile Acids Level in Plasma in Patients with Liver Diseases and Its Clinical Significance
スポンサーリンク
概要
- 論文の詳細を見る
Bile acids are manufactured by the hepatic epithelial cells and belong to the main constituents of the bile, which is excreted into bile capillaries and leaves the liver through the intrahepatic bile duct system to reach the duodenum via the extrahepatic bile tract. The liver plays an important role in the formation and excretion of bile acids. The metabolism of bile acids, therefore, can be disturbed by reduced formation caused by hepatic damage, reduced biliary excretion or decreased hepatic uptake of absorbed bile acid. To clarify this situation, total and basic bile acid levels in plasma were estimated according to the method of Sandberg et al. in 192 patients with liver diseases and in 20 normal subjects as a control group. Based on the results of this investigation, it can be said that the quantities of total and basic bile acids increased in liver diseases and that statistically significant positive correlations were found between the elevated total bile acid levels in plasma and GOT, GPT, total bilirubin levels, AP, LAP, gamma-GT and BSP-retention in plasma. The causes of increased bile acid levels, however, are complex and include excessive synthesis due to diminished bile acid concentration in the portal vein blood, permeability disturbances and secretion disturbances in the parenchymal cells. As stated above, elevated total and basic bile acid levels in plasma remain, leading to a blood chemical and morphological standstill in hepatic inflammatory changes. This means that the metabolism of bile acids may reflect the pathophysiological conditions of liver diseases more sensitively than the routinely applied diagnostic parameters. In this way, bile acid levels in plasma can be utilized as a diagnostic procedure in liver diseases.
- 東海大学の論文
著者
-
Sugimoto Eiichi
Department Of Internal Medicine School Of Medicine Tokai University
-
Iwamura Kenichiro
Department Of Internal Medicine Iii School Of Medicine Tokai University
関連論文
- A Case of Porphyria Cutanea Tarda with Hemangioma of the Liver
- Evaluation of Blood Cultures Following Laparoscopy
- A Case of Polycystic Disease of the Liver and the Kidney Associated with Cerebral Aneurysm and Fulminant Hepatitis
- Clinical Significance of Estrogens in Chronic Aggressive Hepatitis
- Clinical Significance of Estrogens in Chronic Aggressive Hepatitis : Estrogen Value in Blood and its Clinical Significance in Patients with Chronic Aggressive Hepatitis
- Current Status of Cancer of the Digestive System at The Tokai University Hospital,with Special Regards to Epidemiologic Considerations
- Multiple Primary Cancers A Report of Five Cases Involving Digestive Organs
- Evaluation of Cirrhosis by Laparoscopy : Clinical and Histopathological Observations of One Hundred Cases of Nodular Liver
- Clinical Studies on Gallstone Dissolution by Chenodeoxycholic Acid
- Spontaneous Spleorenal Shunt and Its Clinical Significance in a Case of Liver Cirrhosis
- Effect of Long-term Administration of Paromomycin Sulfate on the Level of Serum Albumin and γ-globulin in Human Cirrhosis
- Japanese Adult Siblings with Tangier Disease and Statistical Analysis of Reported Cases
- Clinicopathological Aspects of Primary Hepatocellular Carcinoma Occurring in Patients with Liver Cirrhosis
- A Contribution to Early Diagnosis of Primary Hepatic Cell Carcinoma Occurring in Patients with Liver Cirrhosis
- Laparoscopical and Histological Abnormalities of the Liver in Chronic HBs Ag (Hepatitis B Surface Antigen) Carriers
- Clinical Significance of Blood Biochemical Liver Function Tests in Asymptomatic Chronic HBs Ag Carriers
- A Case of Focal Fatty Change of the Liver : A Rare Clinical Entity
- Clinical Study on Etiologic Aspects of Primary Hepatocellular Carcinoma
- Two Cases of Congenital Absence of the Left Hepatic Lobe
- Bile Acids Level in Plasma in Patients with Liver Diseases and Its Clinical Significance
- Therapeutic Utilization of Laparoscopy in Liver Abscess Cases
- Acute Type B Viral Hepatitis Due to Accidental Transfusion of Blood Containing HBs Ag in a Patient with Liver Cirrhosis
- Incidence and Clinical Significance of Mitochondrial Glutamic Oxaloacetic Transaminase in Blood Serum in Patients with Liver Diseases
- Endogenous Bile Acid Tolerance Test and Its Clinical Significance : Series of Total Bile Acid Levels in Plasma before and after Contraction of the Gallbladder in Patients with Chronic Liver Diseases
- Pathogenetic Significance of Bile Acid Metabolism in the Postcholecystectomy Syndrome
- Laparoscopic and Histologic Abnormalities of the Liver in Chronic Asymptomatic Hepatitis B Surface Antigen Carriers
- Clinical Aspects of Bile Acid Metabolism in Liver Diseases
- Clinical Aspects of Modern Hepatology
- Hepatic Involvement of Schistosomiasis Japonica
- Clinical Significance of Estrogens in Chronic Aggressive Hepatitis : Interrelation between Transaminase Activity and Estrogen Level in Relation to the Menstrual Cycle
- Clinical Aspects of Primary Carcinoma of the Liver