Incidence and Clinical Significance of Mitochondrial Glutamic Oxaloacetic Transaminase in Blood Serum in Patients with Liver Diseases

概要

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In 1960, two glutamic oxaloacetic transaminases were separated by paper electrophoresis. One of these was of mitochondrial origin (GOT_m) and the other was confined to the cytoplasm (GOT_s). It is more difficult to liberate GOT_m into blood serum than GOT_s and it is suggested that GOT_m activity can be elevated in blood serum only when the liver is severely injured. Therefore, the incidence and the clinical significance of GOT_m in blood serum must be investigated. In 13 patients (68%) in the florid stage of acute viral hepatitis, the activity of serum GOT_m was in the 30-40 IU range, while the activity of GOT_m was slight during convalescenece. In 8 patients (32%) with chronic aggressive hepatitis, the activity of serum GOT_m was in the 10-20 IU range and in 2 patients (16%) with chronic persistent hepatitis, 22 patients (81%) with fatty liver, and 9 patients (19%) with liver cirrhosis, serum GOT_m activity was generally less than 10 IU. Based on these findings, it can be said that serum GOT_m activity can be recognized in patients with acute and chronic diseases of the liver. The mechanism of the appearance of GOT_m in blood serum and the clinical significance of GOT_m remain unsolved.
東海大学の論文