Hepatic Involvement of Schistosomiasis Japonica
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概要
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Granulomatous hepatitis can be morphologically defined as an inflammatory process of the liver which brings forth granuloma in the intralobular as well as the portal area, and can be divided into two types; specific granulomatous hepatitis and non-specific granulomatous hepatitis. In the former, specific granuloma in the sense of a histologically characteristic constitution and constituents can be found, and the recognition of specific granuloma makes it possible to diagnose the disease. In the latter, a non-specific reactive inflammatory process is found histologically and this means hepatic involvement of systemic diseases or diseases of other organs. In specific granulomatous hepatitis, the clinical significance of the granulomatous inflammatory process seems to come into question because it has been mostly confirmed by chance in liver biopsies and it has been encountered rather seldom in practice. Among cases of specific granulomatous hepatitis, hepatic involvement of schistosomiasis japonica is relatively often encountered clinically, therefore, this paper gives the clinical significance of hepatic involvement of schistosomiasis japonica on the basis of the author's own experience. Hepatic cirrhosis was confirmed histologically in nine out of ten patients, and in two of them, hepatoma based on parasitical cirrhosis of the liver was found. In three of these nine patients, an early history of jaundice, and in six of them, a habit of drinking more than 360 ml rice wine every day were noted. Although tests for HB-antigen and antibody were negative, these nine patients must have had many opportunities to be infected with hepatitis virus over the long period of time after schistosoma japonica infection. Therefore, it has been said that hepatic involvement of schistosomiasis japonica itself does not become worse unless additional factors are involved in the disease.
- 東海大学の論文
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