Clinical Significance of Estrogens in Chronic Aggressive Hepatitis : Interrelation between Transaminase Activity and Estrogen Level in Relation to the Menstrual Cycle
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Clinical investigations of estrogens in patients with chronic aggressive hepatitis in menopause after bilateral ovariectomy showed that deficiencies of estrogens must be considered as an important factor in the pathogenesis of chronic aggressive hepatitis. To confirm this, transaminase activity in blood serum and urinary excretion of estrogens in relation to the menstrual cycle were estimated in healthy conceptive women and in patients with chronic persistent hepatitis after unilateral ovariectomy. The results revealed a reverse interrelation between the fluctuation of transaminase activitv and that of urinary excretion of estrogens in relation to the menstrual cycle, and it appeared that estrogens have a certain protective influence on the liver and that a deficiency of estrogens has an unfavorable influence on the pathogenesis of chronic aggressive hepatitis.
- 東海大学の論文
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