結核菌に対する化学療法剤の研究(第24報) : 3-Methoxy-2-phenoxybenzaldehyde, 3-Methoxy-4-(3-methoxyphenoxy)benzaldehyde および 3-Methoxy-4-(4-methoxyphenoxy) benzaldehyde誘導体の合成ならびに抗結核菌作用について

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Comparative examinations were made on the antibacterial action of 3-methoxy-2-phenoxybenzaldehyde and 21 kinds of its derivatives, 3-methoxy-4-(3-methoxyphenoxy)-benzaldehyde and 22 kinds of its derivatives, and 3-methoxy-4-(4-methoxyphenoxy)-benzaldehyde and 23 kinds of its derivatives against sensitive strain of human tubercle bacilli H37Rv, using Tween-albumin medium. Comparison of 3-methoxy-4-phenoxy-benzaldehyde derivatives reported previously^<1)>and the present series of compounds showed that in compounds with one methoxyl, presence of a phenoxy group para to the formyl group had better antibacterial activity than those with the phenoxyl ortho to the formyl group. Compounds with two methoxyl groups had lower antibacterial activity than those with one methoxyl. In the series of compounds reported in the present paper, with the same skeleton on the right-hand side, the compounds possessing a methoxyl meta to the bridged oxygen showed an antibacterial activity while those with methoxyl para to the bridged oxygen hardly showed any activity. The thiosemicarbazones of the three compounds reported in the present series showed no increased antibacterial action by substitution of the hydrogen in 4-position of the thiosemicarbazono group with alkyl or aryl but such increased antibacterial action was observed in the case of 3-methoxy-4-phenoxybenzaldehyde thiosemicarbazone reported previously.^<1)>
社団法人日本薬学会の論文
1969-09-25