結核菌に対する化学療法剤の研究(第19報) : 2-Pyrrolecarboxaldehyde, 2,4-Dihydroxy-5-ethylbenzaldehydeおよび2,4-Dihydroxy-5-isoamylbenzaldehydeの誘導体の合成ならびに抗菌作用について

概要

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Nineteen kinds of 2-pyrrolecarboxaldehyde derivetives and 41 kinds of 5-ethylbenzaldehyde and 2,4-dihydroxy-5-isoamylbenzaldehyde derivatives were synthesized and their antibacterial activity was tested using a sensitive strain of human type tubercle bacilli H37Rv and a multiple resistant strain, H37RvR, which is resistant to 300μg./ml. of streptomycin, 50 μg./ml. of INAH, and 50μg./ml. of PAS. In contrast to the growth-inhibition of H37RvS strain at 0.0625μg./ml. of INAH and 12.5μg./ml. of TBI, thiosemicarbazone, 4-methyl-thiosemicarbazone, 4-ethylthiosemicarbazone, and 4-phenylthiosemicarbazone of 2-pyrrolecar-boxaldehyde inhibited the growth of these strains at 3.13μg./ml. 4-Methylthiosemicarbazone and 4-phenylthiosemicarbazone showed a fairly strong antibacterial action against H37RvR strain at 3.13μg./ml., in contrast to 12.5μg./ml, of TBl used as control. However, none of the derivatives of 2,4-dihydroxy-5-ethylbenzaldehyde and 2,4-dihydroxy-5-isoamylbenzaldehyde showed a strong antibacterial activity.
社団法人日本薬学会の論文
1967-12-25