飲食物防腐剤の研究(第72報) : Diphenyl Ether誘導体, Biphenyl誘導体およびDibenzofuran誘導体の清酒防腐剤としての研究

概要

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Antibacterial tests against Bacillus saprogenes, which causes putrefaction of Sake, were carried out on 22 kinds of diphenyl ether series compounds, two kinds of dibenzofuran series compounds, and four kinds of biphenyl series compounds. In diphenyl ether series compounds, four compounds having a hydroxyl group in one benzene ring and a methyl in the other benzene ring, such as 2-hydroxy-2'-methyldiphenyl ether and 4-hydroxy-4'-methyldiphenyl ether, and a compound with a formyl and a hydroxyl in the same benzene ring, such as 4-formyl-2-hydroxydiphenyl ether, had antibacterial power 4-8 times that of salicylic acid and 2-4 times that of butyl p-hydroxybenzoate. Substitution of the methyl group with carboxyl lowered the antibacterial activity. In biphenyl derivatives, 2,2'- and 4,4'-dihydroxybiphenyl had antibacterial activity 8 times that of salicylic acid and 4 times that of butyl p-hydroxybenzoate. Increasing number of the hydroxyl group lowered the antibacterial activity. In dibenzofuran compounds, 3,7-dihydroxydibenzofuran had twice the antibacterial activity of salicylic acid and about comparable to butyl p-hydroxybenzoate. 3,7-Dihydroxy-1,9-dimethyldibenzofuran increased the antibacterial activity to 8 times that of salicylic acid and 4 times that of butyl p-hydroxybenzoate, showing that increase of methyl groups resulted in stronger antibacterial activity.
社団法人日本薬学会の論文
1971-09-25