結核菌に対する化学療法剤の研究(第26報) : Phenylthiourea, p-Ethoxyphenylthioureaおよび3-Bromo-4-ethoxyphenylthiourea誘導体の合成ならびに抗結核菌作用について

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A total of 75 kinds of compounds, comprising 27 kinds of phenylthiourea derivatives, 25 kinds of p-ethoxyphenylthiourea derivatives, and 23 kinds of 3-bromo-4-ethoxyphenylthiourea derivatives, were synthesized and screened for antibacterial activity using sensitive strain of human-type tubercle bacilli H37Rv with Tween-albumin medium, by the in vitro multiple dilution method. Inhibition of bacillary growth by the control agents was found in 0.0313 μg/ml of INH, 0.08-0.156 μg/ml of TBI, 0.313 μg/ml of PAS, and 1.56-3.13 μg/ml of DAT, but none of the synthesized compounds showed better activity, growth inhibition being seen with 3.13 μg/ml of 1-phenyl-3-(4-dimethylaminophenyl)-2-thiourea and with 6.25 μg/ml of 1-phenyl-3-(2-ethylhexyl)-, 1-(4-ethoxyphenyl)-3-(4-bromophenyl)-, 1-(4-ethoxyphenyl)-3-(4-acetylphenyl)-, 1-(4-ethoxyphenyl)-3-(4-butoxycarbonylphenyl)-, and 1-(4-ethoxyphenyl)-3-(2-diphenyl)-2-thioureas.
社団法人日本薬学会の論文
1971-02-25