非定型抗酸菌の諸種薬剤に対する感受性-1-抗結核剤に対する感受性

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The sensitivity of 36 atypical mycobacterial strains to various antituberculous drugs was studied in vitro using Dubos Tween Albumin liquid medium. The drugs tested were SM, PAS, INH, KM, 1314 TH, CS, VM, EB, DAT and RFP. The atypical mycobacterial strains were made up as follows: 5 strains of photochromogens (M. kansasii), 8 strains of scotochromogens and 23 strains of nonphotochromogens (M. intracellulare). One strain of Mycobacterium tuberculosis, H37Rv, was also tested in the same conditions as a control. Any drug was evaluated tentatively as sensitive to these strain s, if its Minimal Inhibitory Concentration (MIC) was 0.78 mcg/ml or less, or within four times of the MIC against M. tuberculosis H37Rv. On the b asis of these criteria, over fifty per cent of the photochromogenic strains (M. kansasii) were sensitive to SM (60), INH (80), 1314TH (100), CS (100), VM (100), EB (100), DAT (100) and RFP (80). (The numbers in the parentheses are the percentages of the sensitive strains.) Likewise, over fifty per cent of the scotochromogens were sensitive to CS (100), VM (75), EB (100) and RFP (75), and over fifty per cent of the nonphotochromogens (M. intracellulare)were sensitive to CS (100), EB (83) and RFP (57).
一般社団法人日本結核病学会の論文