結核菌の発育に不適当な条件と化学療法-5-培養温度と化学療法剤の効果-2-

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Chemotherapeutic effects of RFP alone, two-drug regimen of RFP·EEB and threedrug regimen of RFP·EEB·EINH to Mycobacterium tuberculosis H37Rv were evaluated in vitro by changing the incubating temperature at 37°C, 25°C and 4°C. Comparing the results obtained at 25°C and 4°C with thos e at 37°C, the chemotherapeutic effects were remarkably lowered in the latter even in the three-drug regimen and the development of drug-resistance to RFP was not observed in such an inadequate condition for the growth of tubercle bacilli. According to these results, it seems almost impossible to intensify the antituberculosis chemotherapeutic effect under the thermal condition inadequate for the growth of tubercle bacilli in vitro.
一般社団法人日本結核病学会の論文