実験的非定型抗酸菌症に関する研究-6-実験的Mycobacterium fortuitum症作成と治療の試み

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Chemotherapeutic effects To sulfisoxazole (SIZ), KM-ETH, and KM-ESIZ were evaluated ona murine experimental M. fortuitum infection using large intravenous inocula of M. fortuitum, TMC 1529 (ATCC 6841).<BR>The strain produced highly uniform and advanced kidney lesions (abscess) two to four weeks after the infection, and "spinning disease" was observed in some of the mice, thoughthe incidence was relatively low. Body weights of the mice decreased conspicuously shortlyafter the infection and the nadir was observed around two to three weeks after the infection.<BR>The gradual uprise was observed thereafter, although they never reached normal levels duringthe experimental period. Spontaneous regressions of the kidney lesions were suggested byfrequent recognitions of cicatricial residues at the final autopsy (at the 7th week after infection). These findings were demonstrated also in the three treated groups, and the in vivo effectsof KM-ETH, SIZ and KM-ESIZ were all equivocal and definite conclusions were not obtained, although macroscopic kidney lesions as well as microscopic liver, spleen and kidney lesionstended to be less extensive in the groups treated with KM-ETH and KM-ESIZ. The number ofculturable bacilli in the kidney beyond 5 days after the infection differ widely from kidneyto kidney even in the untreated group, and it was difficult to use the numbers of recoveredbacilli from kidneys as an index of in vivo effects of the regimens tested.<BR>An additional evaluation of culturable bacilli from lungs, spleens and kidneys of ddYconventional mice at more frequent intervals in a relatively short period of time after infectiondemonstrated a rapid decrease of culturable bacilli in these three organs simultaneously andrecovered bacilli were negligible beyond seven days after the infection.<BR>Macroscopic kidney lesions could be used as an index for future in vivo evaluation ofthe drugs against M. fortuitum infection, although meticulous comparisons between untreatedand treated mice seem to be necessary. However, the tendency of spontaneous regression ofthe kidney lesions, and of a rapid decrease of culturable bacilli from the organs of mice ina week or so with unpredictable recoveries of bacilli from kidney beyond the period demonstrated in the two experiments herein presented demand further studies for making moresuitable models of M. fortuitum infection.
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実験的非定型抗酸菌症に関する研究-6-実験的Mycobacterium fortuitum症作成と治療の試み

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