結核菌に対する化学療法剤の研究(第17報) : Indole-3-carboxaldehyde誘導体の合成ならびに抗菌作用について

概要

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Antibacterial action against human tubercle bacillus, was tested with 23 kinds of indole-3-carboxaldehyde derivatives, including 4-alkylthiosemicarbazones, 4-arylthiosemicarbazones, benzoylhydrazones, and amidinohydrazone hydrochlorides. The microorganisms tested were sensitive strain of H37Rv and heavy resistant strains resistant to 300 γ/ml. of streptomycin, 50γ/ml. of p-aminosalicylic acid, and over 50γ/ml. of isonicotinic acid hydrazide. While the control INAH inhibited the growth for 4 weeks at 0.25 γ/ml. and TBI at 50 γ/ml., most of the compounds tested inhibited the growth at 25 γ/ml. concentration. Therefore, there seemed to be none with excellent antibacterial activity but these compounds were found to have bacteriostatic activity in vitro two times stronger than that of TBI.
社団法人日本薬学会の論文
1966-09-25