マウス実験結核症を用いた強化化学療法の研究

概要

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Mice were infected intravenously with Mycobacterium tuberculosis, and all the mice were observed without any treatment for one week to ensure the formation of suitable chronic lesions. As the anti-tuberculous drugs, isoniazid (INH), rifampicin (RFP), ethambutol (EB), and pyra-zinamide (PZA) were employed in this experiment. The mice were divided into five groups according to the regimen of chemotherapy. The first group was treated with INH·RFP·EB, the second one with INH·RFP·PZA, the third one with INH·PZA, the fouth one with INH alone and the fifth one remained untreated as the control. After giving chemotherapy for eight weeks, viable count of tubercle bacilli recovered from the lungs and spleens of the treated mice were recorded and compared with those of the untreated mice. It was confirmed that the chemotherapy with the combination of INH·RFP·EB or INH·RFP·PZA was more effective than that with INH alone or INH·PZA. Although the population of tubercle bacilli recovered from the lungs and spleens of the treated mice has been reduced significantly, tubercle bacilli could not been eradicated by the doses and period of chemotherapy used in this experiment. Number of bacilli in bacteriologically relapsed cases especially treated by regimens containing RFP was smaller than the untreated control. The sensitivity test revealed no emergence of drug resistance to INH, RFP and EB.
日本結核病学会の論文