薬物代謝の研究(第3報) : アミノビリンおよびスルビリン連続投与が肝薬物代謝酵素活性におよぼす影響について

概要

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Effect of continuous administration of aminopyrine, sulpyrine, and their mixture (high and low doses) on drug metabolizing enzyme activities in liver microsomes was examined. The enzyme activities examined were morphine N-demethylase, aminopyrine N-demethylase, and aniline hydroxylase, and male Wistar rats were used. At the same time, effect of long term administration of these drugs on rat body weight and pathohistological examination of the liver were also observed. Body weight increase was considerably inhibited after 40 days, compared to that of the control, and this tendency was especially marked in the high dosage group. Activities of drug metabolizing enzymes in liver microsomes varied with characteristic wave form, though this differed somewhat according to the substrate. Difference between high and low dosages was observed during the initial period after the start of the administration. There was no difference in these activities according to aminopyrine, sulpyrine, and their mixture. Pathohistological observations of the liver revealed no marked change.
社団法人日本薬学会の論文
1968-08-25