運動が脳卒中易発症性高血圧自然発症ラット(SHRSP)の血圧及び脳血管系疾患発症に及ぼす影響

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Many reports (2, 3, 7) indicate that the proper exercise training may have the effect of lowering blood pressure of the essential hypertensives. It is also reported that the blood pressure rise in Spontaneously Hypertensive Rat (SHR) can be repressed by the voluntary exercise. It is considered that if the blood pressure rise of Stroke-prone SHR (SHRSP) can be controlled by the voluntary exercise, an attack of cerebro-vascular lesions and encephalopathy can be prevented by the relations between hypertension and cerebro-vascular lesions. Male SHRSP, 39 in total, 7 weeks old were divided into the exercise group (20) and the control group (19). Each SHRSP of the exercise group was kept in the individual cage with a voluntarily revolving wheel, 1-meter in circumference. A SHRSP of the control group was kept individually in an ordinal cage. All of them were housed in a climate room : temperature : 22-24°C, humidity: 50-60%, for 6 months of duration after 7 weeks of age. Water and foods were provided adlibitum. Weekly running distances of the exercise group, amount of food consumption, body weight and blood pressure were measured, the symptoms of stroke or hypertensive encephalopathy of the rats of both group were observed periodically during the experiment duration. After 6 months, they were killed for pathological examinations, especially for the cerebro-vascular lesions. Though the systolic blood pressure of both groups rose progressively according to aging, the average value of systolic blood pressure of the exercise group were significantly higher than that of control group, after latter half period, contrary to our presumption. Eight of 20 rats in the exercise group died or sacrificed during the experimental period. Abnormal symptoms suggestive of stroke or hypertensive encephalopathy were observed in 7 rats of the exercise group, 2 of the control. Main lesions of the brain were consisted of old softening with gliosis and scattered fresh hemorrhages. The softening and fresh hemorrhages were often observed together in the same rat. There were some different foci of softenings; diffuse or small softenings, cystic one and so on. The familial commonness were observed in the blood pressure rise and the attack of the cerebral lesions. Following results were obtained; 1) The blood pressure rise and the attack of the cerebral lesions are deeply influenced by some inheritance factor. 2) During the prehypertensive phase, the voluntary exercise acts to suppress the blood pressure rise on SHRSP. 3) During the severe hypertensive phase, the voluntary exercise acts to accelerate the systolic blood pressure rise, and it may increase the risk of cerebral apolexy or the attack of encephalopathy on SHRSP.
社団法人日本体育学会の論文
1982-06-01

運動が脳卒中易発症性高血圧自然発症ラット(SHRSP)の血圧及び脳血管系疾患発症に及ぼす影響

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