実験的胎仔胆管造影による胆道閉鎖症肝内胆管異常の知見

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Cholangiogram of postoperative uncorrectable biliary atresia has shown abnormal intrahepatic bile ducts and it was classified into three types; invisible, radiating and main duct. Experimental cholangiogram was performed on fetal rabbits to study development of bile ducts related to the pathogenesis of the abnormal intrahepatic bile ducts in biliary atresia. Cholangiogram was done on fetus of 17 days gestation and thereafter by inserting tube into stomach or gallbladder under microscope. Cholangiogram was impossible on fetus of 17 days as intra- and extrahepatic bile ducts were filled with solid cells proved histologically. On 18 days gestation, vague shadow continueing to extrahepatic bile ducts appeared at the porta hepatis into the liver, but no main intrahepatic bile ducts could be recognized. On 19 days and thereafter, apparent main ducts could be observed. It means that the intrahepatic bile ducts opens at 18 days and develops to show main ducts after 19 days of gestation. Histoligic study of the liver of human fetus revealed that 6 weeks fetus is apparently like that of rabitts of 18 days in that opening of extrahepatic bile ducts is finished but only a few short branches of intrahepatic bile ducts are just open. These results suggest the abnormal pattern of bile ducts in biliary atresia may be attributed to the developmental abnomality due to pathogenic process that occured on various different developmental stages, may be 6 weeks of gestation and thereafter to interrupt the development of biliary system.
日本小児外科学会の論文
1985-08-20

実験的胎仔胆管造影による胆道閉鎖症肝内胆管異常の知見

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