An immunohistochemical examination of keratin in hepatocytes in hepatitis and liver cirrhosis.

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An immunohistochemical examination of keratin, using a polyclonal antibody and four monoclonal antibodies (KL-1, PKK-1, 2, 3), was performed on livers in normal control, acute hepatitis, chronic inactive hepatitis, chronic active hepatitis and liver cirrhosis. In cirrhotic liver, the number of hepatocytes with keratin positivity and with diffuse positivity throughout entire cytoplasm (Diffuse Type) was larger than normal liver. Such hepatocytes were mainly present in the peripheral zones of both hepatic lobules and regenerative nodules, or in and araund the fibrosis localized in a large area. In regenerative micronodules, the number of them was greatest. Diffuse Type was frequently seen in degenerative and pseudoacinar hepatocytes. These results showed that degeneration and regeneration lead to an increase in the amount of keratin and to distribution of keratin throughout entire cytoplasm in hepatocytes. Furthermore, they showed that amount and distribution of keratin in many hepatocytes in regenerative nodules differ from normal hepatocytes.
社団法人日本肝臓学会の論文