Studies on Drug Metabolism. XI. Metabolic Interaction of Aniline and Phenylbutazone on the Liver Microsomal Drug Metabolizing Enzymes

概要

論文の詳細を見る
It has generally known that combinations of drugs often gave repressive effects on each metabolic rate. Here, we report the metabolic interactions of aniline and phenylbutazone hydroxylations. Simultaneous addition of aniline and phenylbutazone as the substrates to the same incubation mixture showed increased activity of phenylbutazone hydroxylation, on the other hand, activity of aniline hydroxylation was reduced than the activities obtained from the additions of each substrate respectively. The increased phenylbutazone hydroxylation was found not only in the case of addition of p-aminophenol, one of the metabolites of aniline, to the same incubation mixture, but in the livers of rats received aniline intraperitoneally relatively short time before sacrifice.
社団法人日本薬学会の論文
1971-02-25