薬物代謝の研究(第2報) : ペントバルビタール長期連続投与(1カ月)による猫の睡眠時間, 肝ミクロゾーム薬物代謝酵素活性の変動とペントバルビタール生体内蓄積について

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Intraperitoneal injection of 35 mg/kg of pentobarbital was given to cats, and sleeping time was measured, taking the time required from the disappearance of eyelid-closure reflex until its recovery as the index. The animals were divided into six groups given the pretreatment 1,3,7,14,21,and 28 times, and the control group, Drug metabolizing enzymes in the liver microsomes of the cats in the treated groups were examined by measuring periodicallies the activities of aminopyrine N-demethylase, aniline hydroxylase, and pentobarbital metabolizing enzyme. At the same time, accumulations of pentobarbital in the plasma, cerebral cortex, cerebral medulla, heart, liver, kidney, fat, and skeletal muscle in the cats were measured to examine their correlation. It was thereby found that the drug-metabolizing enzyme activities increase for about 2 weeks after continuous administration of pentobarbital, then decrease slightly. There were correlation between enzyme activities and sleeping time, and with the amount of pentobarbital accumulated in each organ.
社団法人日本薬学会の論文
1968-08-25