抗腫瘍活性天然薬物の探索 : 特に高等植物を中心にして
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概要
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Sarcoma-180A has been used for screening the antineoplastic components from natural sources, especially from higher plants. The cyclic oligopeptides RA series compounds isolated from Rubia akane are toxic substances against many kinds of tumors. They were studied chemically and biologically. Among of them, RA-VII is the most active compound against animal tumors and adopted to be tested for phase I study after precrinical trials. Sinococuline isolated from Cocculus trilobus, which is an morphinane alkaloid, has also strong antineoplastic activity against many kinds of animal tumors. Some kinds of diterpenes isolated from Casearia sylvestris, a Palaguaian plant, are very toxic for Sarcoma-180A. Moreover, chemical and biological investigations have been applied to the Zingiberaceous plants.
- 公益社団法人日本薬学会の論文
- 1988-09-25
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