過酸化脂質由来アルデヒド, (E)-4-ヒドロキシ-2-ノネナールの生成と分解

概要

論文の詳細を見る
(E)-4-Hydroxy-2-nonenal (HNE) is a major breakdown product of lipid peroxides formed from n-6 fatty acids. This aldehyde has high reactivity towards nucleophilic groups of proteins or nucleic acids, and exerts significant deleterious effects on cell functions and viability. While, HNE in vivo is rapidly metabolized to 4-hydroxy nonenoic acid, 1,4-dihydroxynonene and HNE-glutathione conjugate by enzymatic systems, but the metabolism is depressed in aging and various pathological conditions. HNE may, therefore, play a key role in the initiation and development of oxidative damage in biological system. This review outlines the formation and metabolism of HNE including our proposed mechansim on the toxic effect of the HNE-glutathione conjugate.
公益社団法人日本薬学会の論文
1996-06-30