ベンゾ〔α〕ピレンに関する研究(第2報)コイ肝臓アリルヒドロカーボンヒドロキシラーゼによるベンゾ〔α〕ピレンの代謝

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The liver of Cyprinus carpio was capable of metabolizing benzo [α] pyrene to 3-hydroxybenzo [α] pyrene. The enzyme system, localized in the 105000×g sedimented pellet (microsomal fraction) of liver homogenate, has an absolute requirement for NADPH, and a partial requirement for MgCl_2. The enzyme activity was detected in the liver and kidneys, but not in the gill, intestine, heart, or spleen of the fish. The enzyme was inhibited by KCN, NaN_3,cytochrome c, and SKF 525-A, which are known to be the inhibitor of hepatic monoxygenase in mammals. It was also strongly inhibited by 7,8-benzoflavone and vitamin A which are known as inhibitors of the mammalian cytochrome P 448-linked oxidative enzyme system.
公益社団法人日本薬学会の論文
1979-08-31