ピリミジン部2位置換ビタミンB_1誘導体の補酵素作用 : (I) 2'-nor-Thiamineおよび2'-Ethylthiamineの生物活性

概要

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2'-nor-thiamine and 2'-ethylthiamine, 2'-methyl group of pyrimidine moiety of thiamine is substituted by H, C_2H_5,respectively, showed the activity of 22,89% to that of thiamine in the growth promotion of Kl. apiculata IFO 0630,No significant difference was observed in their permeability to the cells of the yeast and in their phosphorylation to 2'-nor-thiamine or 2'-ethylthiamine pyrophosphate by thiamine pyrophosphokinase. The lower activities of these thiamine derivatives to Kl. apiculeta should therefore be explained by their weak coenzymic activity to thiamine requiring enzymes such as pyruvate decarboxylase (PDC) or transketolase. The activities of 2'-nor- and 2'-ethylthiamine pyrophosphate to PDC were 5-6% and 25-27%, respectively, to that of thiamine pyrophosphate. The discrepancy between the growth promoting activity and PDC activating effect of these derivatives is discussed.
日本ビタミン学会の論文
1969-11-25