Characterization of Fibronectin-Related Substances in Normal and Passive Heymann Nephritis Rats
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概要
- 論文の詳細を見る
The excretion mechanism of fibronectin (FN)-related substances into the urine of normal and passive Hey-mann nephritis (PHN) rats was studied using enzyme immunoassay and immunoblot analysis. In normal rats, a small amount (0.20±0.67 μg/d) of FN-related substances, composed of 55- and 65-kDa FN fragments derived from the central cell-binding (Cell) domain of FN, were constitutively excreted into the urine. When PHN was induced in rats by the injection of an anti-Fx1A antibody, an increased excretion (4.96±3.51 μg/d) of intact FN and large (M_r>100-kDa) FN fragments containing the Cell and the other functional domains were seen. The PHN induction also caused the appearance of a considerable amount of Cell domain-containing FN fragments in plasma. Both the renal cortex homogenates of normal and PHN rats were capable of degrading plasma FN to generated the Cell domain-containing large FN fragments. Degradation of FN by the renal cortex homogenate was shown to be due to metal and/or thiol proteinase(s). These results suggest that the PHN-induced urinary excretion of FN fragments may be due to the degradation of plasma FN by renal proteinases that may be leaked upon PHN induction.
- 公益社団法人日本薬学会の論文
- 1998-05-15
著者
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NISHIZAWA YOSHINORI
Department of Fermentation Tachnology, Faculty of Engineering, Hiroshima University
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Nishizawa Yoshinori
Department Of Applied Chemistry And Chemical Engineering Faculty Of Engineering Yamaguchi University
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Nishizawa Y
Kao Corp. Tochigi Jpn
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FUKAI Fumio
Department of Patho-Physiology, Faculty of Pharmaceutical Science, Tokyo University of Science
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Fukai F
Tokyo Univ. Sci. Chiba
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Fukai Fumio
Department Of Patho-physilogy Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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NATORI Yasuhiro
Division of Pathophysiology, Research Institute, International Medical Center of Japan
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KATAYAMA Takashi
Department of Patho-Physiology, Faculty of Pharmaceutical Sciences, Sciences University of Tokyo
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Natori Yasuhiro
Division Of Pathophysiology Research Institute International Medical Center Of Japan
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Katayama Takashi
Department Of Patho-physiology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Katayama Takashi
Department Of Patho-physiology Faculty Of Pharmaceutical Sciences Sciences University Of Tokyo
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Funai Fumio
Department of Patho-Physiology, Faculty of Pharmaceutical Sciences, Sciences University of Tokyo
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Katayama Takashi
Department of Chemical Engineering, Faculty of Engineering Science, Osaka University
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