Dihydrotestosterone-binding protein in cytosols of normal and hypertrophic human prostates, and influence of estrogens and anti-androgens on the binding.
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概要
- 論文の詳細を見る
Dihydrotestosterone-binding protein was observed in cytosols of the normal and hypertrophic human prostates. Association constant for dihydrotestosterone of cytosol of the normal prostate differed slightly from that of the hypertrophic prostate. However, maximum binding capacity was almost identical in these tissues. No distinct correlation was detected between proportion of glandular constituent and binding characteristics (Ka and maximum binding capacity) in the hypertrophic prostates.<BR>Influence of some steroids on the binding with dihydrotesterone was examined. Testosterone, estradiol-17β, estriol, cyproterone acetate and SK & F 7690 inhibited the binding competitively. However, Sch 13521 did not exhibit any influence on the binding.
- 社団法人 日本内分泌学会の論文
著者
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Kodama Takaomi
Department Of Urology Graduate School Of Medicine Chiba University
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WAKISAKA MASAMI
Department of Urology, School of Medicine, Chiba University
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Katayama Takashi
Department Of Patho-physiology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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SHIMAZAKI JUN
Department of Dermatology, School of Medicine, Chiba University
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