Carcinoembryonic antigen and endocrine response in a patient with Sipple's syndrome following surgery.
スポンサーリンク
概要
- 論文の詳細を見る
Circulating carcinoembryonic antigen (CEA), calcitonin (CT) and adrenocorticotropic hormone (ACTH) and levels in tissue extracts of a patients with Sipple's syndrome were measured simultaneously. Biofocal medullary carcinoma of the thyroid gland (MCT), left adrenal phaeochromocytoma and ectopic paraaortal phaeochromocytoma had been removed in the first operation. Total thyroidectomy was performed thereafter. Evidence has been presented showing that (1) the first operation lowered the elevated serm levels of CEA and CT, and levels of CEA and CT in tissue extracts of MCT were considerably higher than those of tumor-uninvolved thyroid tissue and phaeochromocytomas (2) markedly elevated levels of plasma ACTH were normalized by the first surgery and, in addition, immunoreactive ACTH and beta-melanocyte stimulating hormone (β-MSH) were detected in the phaeochromocytomas removed.<BR>This is a documented case of the simultaneous production of CT and CEA by MCT associated with ectopic secretion of ACTH and β-MSH from the phaeochromocytomas without manifesting clinical features of Cushing's syndrome and is based on the findings referred to above.
- 社団法人 日本内分泌学会の論文
著者
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Nagayama Tadao
Division Of Urology Chiba Cancer Center Hospital
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Katayama Takashi
Department Of Patho-physiology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Nakada Teruhiro
Department Of Urology Chiba University School Of Medicine
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Shigematsu Hidekazu
Department Of Medicine And Clinical Science Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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SHIGEMATSU HIDEKAZU
Department of Pathology, Chiba University, School of Medicine
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MIYAUCHI TAKEHIKO
Divisions of Urology, Chiba University, School of Medicine
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YOSHIDA YUTAKA
Anaesthesiology, Chiba University, School of Medicine
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SAKIYAMA SHIGERU
Biochemistry, Chiba University, School of Medicine
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SHIMADA FUMIYUKI
Head & Neck, Chiba Cancer Center, Chiba University, School of Medicine
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KATAYAMA TAKASHI
Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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NAKADA TERUHIRO
Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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NAGAYAMA TADAO
Divisions of Urology, Chiba University, School of Medicine
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