Enhanced protein synthesis of heart in adrenal-regeneration hypertension and its reduction following antihypertensive treatment.
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概要
- 論文の詳細を見る
After unilateral nephrectomy and bilateral adrenal enucleation at 5 weeks of age, salt-loaded rats developed hypertension (ARH) at 6 weeks. Fibrous vascular protein and in vivo incorporation of 3H-lysine into this protein fraction were measured at 15 weeks of age in these animals.This study demonstrates: (1) that incorporation rates of 3H-lysine into cardiac collagen and elastin in ARH rats were greater than in control rats (p<0.001, respectively), and (2) that administration of phenoxy-benzamine hydrochloride decreased the incorporation of tritiated lysine into cardiac collagen in ARH rats, concomitant with a reduction in blood pressure. Based on these findings, increased synthesis of cardiac collagen and elastin appears to play an important role in the development of hypertension in ARH.
- International Heart Journal刊行会の論文
著者
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Katayama Takashi
Department Of Patho-physiology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Nakada Teruhiro
Department Of Urology Chiba University School Of Medicine
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KATAYAMA Takashi
Department of Urology, Faculty of Medicine, Toyama Medical & Pharmaceutical University
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YAMAZAKI Norimasa
Department of Urology, Faculty of Medicine, Toyama Medical & Pharmaceutical University
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AKIYA Tohru
Department of Urology, Faculty of Medicine, Toyama Medical & Pharmaceutical University
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AKIYA Tohru
Department of Urology, Faculty of Medicine, Toyama Medical & Pharmaceutical University
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NAKADA Teruhiro
Department of Urology, Faculty of Medicine, Toyama Medical & Pharmaceutical University
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YAMAZAKI Norimasa
Department of Urology, Faculty of Medicine, Toyama Medical & Pharmaceutical University
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