Measurement of androgen receptor in cytosols from normal, benign hypertrophic and cancerous human prostates.
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概要
- 論文の詳細を見る
The binding of R 1881 in cytosols from the normal, benign hypertrophic and cancerous human prostates was examined in the presence of molybdate and triamcinolone acetonide. The addition of 10mM Na<SUB>2</SUB>MoO<SUB>4</SUB> resulted in an increase in the stability of the binder without any change in Kd. Triamcinolone acetonide added to the incubation of cytosol with R 1881 modified the inhibition pattern by other steroids, and the binding in the presence of triamcinolone acetonide exhibited the characteristics of androgen receptor. The complex of cytosol and R 1881 formed in the incubation in the presence of triamcinolone acetonide was sedimented at 8.5S.<BR>Kd of the binding to R 1881 of the normal and pathological prostates was almost identical, but maximum binding sites of the androgen receptor were larger in benign hypertrophic and cancerous prostates than in normal tissues. For the assay of binding capacity in needle biopsy specimens, one point determinations were performed using 2.5nM R 1881 as the ligand. The number of binding sites obtained by this method were well correlated with those obtained by the Scatchard plot in various prostatic tissues.
- 社団法人 日本内分泌学会の論文
著者
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Hikage Takashi
Department Of Urology Tokyo Kosei Nenkin Hospital
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Kodama Takaomi
Department Of Urology Graduate School Of Medicine Chiba University
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Ito Haruo
Department Of Pharmacology Kanagawa Dental College
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Sato Ryoko
Department Of Cardiology Kanazawa Medical University
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SHIMAZAKI JUN
Department of Dermatology, School of Medicine, Chiba University
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HIKAGE TAKASHI
Department of Urology, School of Medicine, Chiba University
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