FREE RADICALS-INDUCED CHANGES IN MESENTERIC MICROVASCULAR DIMENSIONS IN THE ANESTHETIZED CAT
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概要
- 論文の詳細を見る
Effect of free radicals on microvascular dimensions was studied in anesthetized cat intestinal mesentery. Generation of free radicals by xanthine oxidase, acting on endogenous substrates (e.g., xanthine, hypoxanthine), produced sustained vasodilation at pH 7.4 or at pH 6.6. These effects were reversed by superoxide dismutase (SOD), a superoxide radical (·O<SUB>2</SUB><SUP>-</SUP>) scavenger, at pH 7.4, and by SOD plus hydroxyl radical (·OH) scavenger d-mannitol at pH 6.6. These findings suggest that the sustained vasodilation is caused by ·O<SUB>2</SUB><SUP>-</SUP> and by ·OH derived from ·O<SUB>2</SUB><SUP>-</SUP> at low pH.
- 社団法人 日本薬理学会の論文
著者
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Okabe Eiichiro
Deparment Of Pharmacology Kanagawa Dental College
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Ito Haruo
Department Of Pharmacology Kanagawa Dental College
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TODOKI Kazuo
Department of Pharmacology
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ODAJIMA Chisato
Department of Pharmacology, Kanagawa Dental College
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ITO HARUO
Department of Pharmacology, Kanagawa Dental College
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