EFFECTS OF PERHEXILINE ON MYOCARDIAL PHOSPHORYLASE ACTIVITY, MYOCARDIAL CATECHOLAMINE CONTENT AND HEART RATE
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概要
- 論文の詳細を見る
A study was conducted on the effects of perhexiline on myocardial phosphorylase activity, myocardial catecholamine content and heart rate. Phosphorylase a activity and heart rate were investigated as an indicator of sympathetic nerve tone in order to clarify the characteristic of perhexiline with regard to the effects on myocardial metabolism in hyperthyroid rats and catecholamine deficient rats. Myocardial catecholamine and phosphorylase a activity were measured by von Euler's method and Cori's method respectively. Conclusion of this study are summarized as follows: 1) Perhexiline reduces the heart rate, and its effect is not always dependent upon the changes in myocardial norepinephrine content. 2) Perhexiline reduces myocardial phosphorylase a activity. It cannot be always said that the reduction is dependent upon the changes in myocardial norepinephrine. 3) Though slightly different from propranolol and dichloroisoproterenol, perhexiline possesses cardiac effects resembling β-blockers.
- 社団法人日本循環器学会の論文
- 1981-06-20
著者
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ITO HARUO
Department of Urology, Chiba University
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OKABE Eiichiro
Department of Pharmacology and ESR Laboratory, Kanagawa Dental College
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Okabe Eiichiro
Deparment Of Pharmacology Kanagawa Dental College
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Cho Young
Clinical Pharmacology University Of North Carolina School Of Medicine
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Higashi Hiroshi
Departlnent Of Pathology Scrpporo Medical College
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Higashi Hiroshi
Department Of Pharmacology Kanagawa Dental College
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FUJISAWA TSUTOMU
Department of Pharmacology, Kanagawa Dental College
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Ito Haruo
Department Of Pharmacology Kanagawa Dental College
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Fujisawa Tsutomu
Department Of Pharmacology Kanagawa Dental College
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ITO HARUO
Department of Pharmacology, Kanagawa Dental College
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