Effect of potassium gluconate on potassium transport of rat erythrocytes.
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概要
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Effect of potassium gluconate (K-GL) on K<SUP>+</SUP> uptake of rat erythrocytes was investigated. K-GL produced a significant increase in active K<SUP>+</SUP> transport of Na<SUP>+</SUP>-rich erythrocytes, while Na<SUP>+</SUP>, K<SUP>+</SUP>-ATPase activity of hemoglobin-free ghosts without a glycolytic system was unaffected. When the experiment was carried out in intact erythrocytes, K-GL increased the lactate production and ATP content, and it promoted the methemoglobin reduction rate. In Na<SUP>+</SUP>-rich erythrocytes, the glycolysis inhibitors which produced a marked reduction in lactate content abolished the K-GL-induced increase in K<SUP>+</SUP> and ATP content without affecting the KCl-induced increase. These results suggest that K-GL enhances K<SUP>+</SUP> transport of erythrocytes through acceleration of glycolytic process.
- 公益社団法人 日本薬理学会の論文
著者
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Okabe Eiichiro
Deparment Of Pharmacology Kanagawa Dental College
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Ito Haruo
Department Of Pharmacology Kanagawa Dental College
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TSUJITANI Michihiko
Research Center, Kayaku Co., Ltd.
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