Properties of Androphilic Proteins in Cytosols of Human Benign Prostatie Hypertrophy
スポンサーリンク
概要
- 論文の詳細を見る
Androphilic proteins in the cytosol from the human benign prostatic hypertrophy are separated into two fractions by Sephadex chromatography; void volume fraction and IgG fraction which was eluted near the site of hIgG. In the present study, properties of these two androphilic proteins were compared. Association constants of these proteins were in the order of10<SUP>9</SUP>M<SUP>-1</SUP>. However, the binding capacity of the former was smaller than that of the latter. These two androphilic proteins well bound to nuclei, and the high-affinity and saturable binding to nuclei was observed in the <SUP>3</SUP>H-dihydrotestosterone-IgG fraction complex, while binding of <SUP>3</SUP>H-dihydrotestosterone-void volume fraction complex to nuclei was low affinity and unsaturable. The binding of the complexes to chromatin seems to be of low affinity and nonsaturable. These androphilic proteins did not bind to calf thymus DNA. Salt extractability of the bound void volume fraction after incubation with nuclei was not different from that of the bound IgG fraction. It was observed that the chromatographic behavior of the androphilic protein in IgG fraction was changed after incubation with nuclei.
- 社団法人 日本内分泌学会の論文
著者
-
Kodama Takaomi
Department Of Urology Graduate School Of Medicine Chiba University
-
Shimazaki Jun
Department Of Ophthalmology School Of Medicine Keio University
-
SHIMAZAKI JUN
Department of Dermatology, School of Medicine, Chiba University
関連論文
- Three Distinct Commonly Deleted Regions of Chromosome Arm 16q in Human Primary and Metastatic Prostate Cancers
- Localization of a Tumor Suppressor Gene Associated With Progression of Human Prostate Cancer Within a 1.2 Mb Region of 8p22-p21.3
- Disposable Eyelid-Warming Device for the Treatment of Meibomian Gland Dysfunction
- Combined Medical and Surgical Treatment of Severe Vernal Keratoconjunctivitis
- Characteristics of Androgen-Independent Growth of Androgen-Responsive Shionogi Carcinoma 115 Cells
- Clinical Evaluation of Serum Prostate-Specific Antigen-Alpha^1-Antichymotrypsin Complex Values in Diagnosis of Prostate Cancer: A Cooperative Study
- PRLTS Gene Alterations in Human Prostate Cancer
- Microsatellite Instability and Other Molecular Abnormalities in Human Prostate Cancer
- Mutational Analysis of CDKN2 (CDK4I/MTS1) Gene in Tissues and Cell Lines of Human Prostate Cancer
- p53 Mutations Occur in Clinical, but Not Latent, Human Prostate Carcinoma
- Significance of prostate-specific antigen-doubling time on survival of patients with hormone refractory prostate cancer and bone metastasis : Analysis on 56 cases of cancer-specific death
- Comparison of Gleason grade and score between preoperative biopsy and prostatectomy specimens in prostate cancer
- Significance of capsular atachment and invasion of cancer tissues prostate cancer
- Change in the ratio of free-to-total prostate-specific antigen during progression of advanced prostate cancer
- Immunohistochemical finding of α-1-antichymotrypsin in tissues of benign prostatic hyperplasia and prostate cancer
- The Impact of HLA-A Matching in Corneal Transplantation
- Prostate-Specific Antigen Levels from a Mass Screening Program Using Highly Sensitive RIA Kits
- Detection and identification of oxalate-degrading bacteria in human feces
- Surgical Approach to Tumor Thrombus of Renal Cell Carcinoma at the Level between Hepatic Vein and Diaphragm
- Endoscopic Treatment of Superficial Bladder Cancer with the Holmium : YAG (Ho : YAG) Laser
- Influence of Osteoarthritis on Serum Marker Levels of Bone Formation and Resorption in Patients with Benign Prostatic Hypertrophy
- Relationship between Prostate-Specific Antigen,Clinical Stage,and Degree of Bone Metastasis in Patients with Prostate Cancer:Comparison with Prostatic Acid Phosphatase and Alkaline Phosphatase
- DISEASE PROGRESSION IN STAGE A PROSTATE CANCER
- RADIATION THERAPY FOR PROSTATE CANCER CONFINED TO PELVIS
- DIURNAL RHYTHM OF SERUM γ-SEMINOPROTEIN IN PATIENTS WITH UNTREATED PROSTATE CANCER: COMPARISON OF THE ORIGINAL AND REVISED ASSAY KITS
- Relationship between Grade of Varicocele and the Response to Varicocelectomy
- Induction of Programmed Death/Apoptosis in Androgen-dependent Mouse Mammary Tumor Cell Line (Shionogi Carcinoma 115) by Androgen Withdrawal
- Treatment of Urinary Stones on an Outpatient Basis by Extracorporeal Shock Wave Lithotripsy using a EDAP LT-01 (+)
- Management of Candida albicans Donor-to-Host Transmission Following Penetrating Keratoplasty
- Changes in Cytosolic Androgen Receptor after Administration of Testosterone of Androgen-Dependent Mouse Mammary Tumor (Shionogi Carcinoma) and Its Sublines of Altered Androgen Dependency
- Low Molecular Weight Component of Androgen Receptor in Cytosols from Benign Hypertrophic Human Prostate treated with High KCl Solution
- Properties and Androgen-Induced Changes of Arginase in Kidney and Ventral Prostate of Rats
- Effects of Testosterone Administration on RNA Synthesis in Kidney of Castrated Rats
- Effect of Sex Hormones on RNA Synthesis of Androgen-Dependent Mouse Mammary Tumor (Shionogi Carcinoma)
- Effects of Inhibitors of Nucleic Acids and Protein Biosynthesis on the Rate of 5α-reduction of Testosterone, the Activity of DNA Polymerase and Nucleic Acid Contents of Testosterone-stimulated Prostate of Rats
- Incorporation of Testosterone and 5α-Dihydrotestosterone into Rat Ventral Prostate in vitro
- Solubilization of Testosterone 5α-Reductase from Nuclear Fraction of Rat Ventral Prostate
- Further Studies on Testosterone 5α-Reduction in Rat Ventral Prostate
- Inhibition of Nuclear Testosterone 5α-Reductase in Rat Ventral Prostate by Estrogens and Anti-Androgens
- Properties of Testosterone 5α-Reductase of Purified Nuclear Fraction from Ventral Prostate of Rats
- Surgical Management of Severe Canaliculitis Due to Intracanalicular Plug Migration Using Fish-Hook-Type Retractors : A Report of Two Patients
- Binding to R 1881 (Methyltrienolone) of Proteins from Human Benign Prostatic Hypertrophy
- Free Amino Acids in the Caput and the Cauda Epididymis of Adult Rats
- Effect of Testosterone Administration on the Free Amino Acids and Conversion of Arginine to Proline and Glutamate in the Rat Ventral Prostate
- 3α-Reduction of 5α-Dihydrotestosterone by Rat Ventral Prostate
- Effects of Estrogen Administration on Testosterone-Induced Growth and Increase in Enzyme Activities in the Ventral Prostate of Castrated Rats
- Reduction of 5α-Position of Testosterone in the Rat Ventral Prostate
- Studies on the Relation between Dermatoses and Bacterial Allergy, with Special Reference to Micrococcus Pyogenes and Streptococcus Hemolyticus
- Binding of Chlormadinone Acetate to Cytosol from Human Benign Prostatic Hypertrophy
- Effect of Hypolipidemia on Testosterone-Stimulated Prostatic Growth in Castrated Rats
- Effect of Estrogen Administration on Activities of Testosterone 5α-Reductase, Alkaline Phosphatase and Arginase in the Ventral and the Dorsolateral Prostates of Rats
- Inhibition by Various Steroids on Dihydrotestosterone Binding to Androphilic Protein in Human Benign Prostatic Hypertrophy
- Androphilic Proteins in Cytosols of Human Benign Prostatic Hypertrophy
- Properties of Androphilic Proteins in Cytosols of Human Benign Prostatie Hypertrophy
- Dihydrotestosterone-binding protein in cytosols of normal and hypertrophic human prostates, and influence of estrogens and anti-androgens on the binding.
- Measurement of androgen receptor in cytosols from normal, benign hypertrophic and cancerous human prostates.
- Progestin-binding protein in human benign prostatic hypertrophy.