Reduction of the Amidine C=N Bond of 7-Aminofurazano (3,4-d)-pyrimidines with Sodium Borohydride
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Reduction of 5-phenyl-7-substituted aminofurazano (3,4-d) pyrimidines with sodium borohydride was undertaken. In a sharp contrast with the cases of amino, alkylamino and tosylamino derivatives, the presence of acetyl group on the C_7-amino function results in the smooth reduction of the amidine C=N bond to give 7-acetamido-6,7-dihydro derivative. The presence of benzoyl group led to the formation of 6,7-dihydro derivative accompanied with loss of benzamide. Analogously, reduction of 5-phenyl-7-ethylthiofurazano (3,4-d) pyrimidine gave the 6,7-dihydro derivative.
- 公益社団法人日本薬学会の論文
- 1976-02-25
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