The Ring Contraction of Pyridazinones to Pyrazoles. V
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概要
- 論文の詳細を見る
In order to explore the scope of the ring contraction of pyridazinone to pyrazole, 2-phenyl-3 (2H)-pyridazinones (IIIa-f) and (IVa-e) having 4 and 5 substituents other than chlorine were prepared and examined their behavior against sodium hydroxide. Among them, (IIIa, b) and (IVa, b, e) undergo the ring contraction to afford the corresponding pyrazole carboxylic acid, (V), (VII), and (VIII). From available data, substituent effects and mechanisms for these ring contractions were discussed. In the course of this study, an unusual displacement reaction was observed in the reaction of 2-phenyl-4-chloro-5-methylthio-3 (2H)-pyridazinone (IIIa) with sodium hydroxide and sodium ethoxide.
- 公益社団法人日本薬学会の論文
- 1971-08-25
著者
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牧 敬文
Gifu College Of Pharmacy
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高谷 昌弘
浜理薬品工業(株)研究所
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高谷 昌弘
Pharmacological Laboratory, Morishita Pharmaceutical Co., Ltd.
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