Thermal Reaction of 4-Benzothiazolyldithioazetidinone Novel Formation of Isothiazolone Derivatives
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In order to compare with the photochemical reaction resulting to the preferential formation of 3-methylenecepham, the thermal reaction of 4-benzothiazolyldithioazetidinone (1) was examined. Pyrolysis of 1 led to the formation of 2-mercaptobenzothiazole (4), isothiazolone derivatives (5a and 5b), thiazole derivatives (6a and 6b) and bisbenzothiazolyl disulfide (7) in a different manner from the photolysis of 1. Rearrangements of 1 to 5 and 6 are particularly of interest and their possible mechanisms were discussed.
- 公益社団法人日本薬学会の論文
- 1978-04-25
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