Pyrimido-1,4-benzothiazines and -1,4-benzothiazepines. I. Oxidative Coupling and Pummerer Rearrangement of Pyrimido-1,4-benzothiazine and Its Sulfoxide
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Pyrimido-(1,4)-benzothiazinedione (I) underwent oxidative coupling with water, alcohols and morpholine at the 4α-angular position in the presence of iodine and base such as triethylamine or morpholine. The facile Pummerer rearrangement of its sulfoxide also give 4α-substituted derivatives. The mechanisms of these reaction are also discussed.
- 公益社団法人日本薬学会の論文
- 1976-12-25
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