Synthesis and Characterization of Nuclear RNA induced by Radix Ginseng Extract in Rat Liver
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概要
- 論文の詳細を見る
The in vivo administration of a fraction obtained by partial purification of radix ginseng extract stimulated the incorporation rate of labeled precursors into nuclear RNA, and a maximum increase was shown at 4 hr after a single dose intraperitoneal injection and the rate returned almost to the control level 24 hr after treatment in a rat. However, the RNA content of nuclei isolated from each interval after treatment is the same in the RNA to DNA ratio as in the control animals. The sedimentation profile by sucrose density gradient of rapidly labled nuclear RNA isolated from the liver of a rat treated with fraction 4 showed a stimulation in the 23s to 7s region which has a peak at 10s region. Rate of the incorporation of labeled precursors into the interphase RNA rather than the nuclear sap RNA was stimulated significantly by fraction 3 and the base composition of this ^<32>P pulse-labeled RNA showed an intermediate value between the ribosamal and DNA-like RNA. The effect of ginseng extract (fraction 3) on the nuclear DNA synthesis was not observed in the present assay by the incorporation of ^3H-thymidine in rat liver.
- 社団法人日本薬学会の論文
- 1971-08-25
著者
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日合 奨
富山医科薬科大学和漢薬研究所
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大浦 彦吉
Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceut
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日合 奨
Department of Biochemistry, Research Institute for WAKAN-YAKU, Toyama Medical and Pharmaceutical Uni
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妹尾 八郎
Department of Biochemistry, Drug Research Institute, Faculty of Pharmaceutical Science, Toyama Unive
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妹尾 八郎
Department Of Biochemistry Research Institute For Wakan-yaku (oriental Medicines) Toyama University
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