Stimulation of the Lipogenic Pathway in Ginsenoside-Rb_2 Treated Rats

概要

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In order to elucidate the effect of ginsenoside-Rb_2 on lipid metabolism, a time course experiment was carried out in rats. The first phenomenon observed was a stimulation of glucose-6-phosphate dehydrogenase activity beginning 4h after the administration of ginsenoside-Rb_2. At this time, a slight increase of acetyl-coenzyme A carboxylase activity was observed, and a significant increase was noted 16h after the treatment. The maximum increase in malic enzyme activity was observed at 12h. An increase in the lipolytic activity of lipoprotein lipase was observed 4h after the intraperitoneal administration of ginsenoside-Rb_2,reaching a maximum (262%) 16h after the treatment, while a repressive effect was observed on hormone-sensitive lipase activity throughout the experimental period. Administration of ginsenoside-Rb_2 to rats also increased the triglyceride content in adipose tissue. These results suggest that ginsenoside-Rb_2 brings about the accumulation of triglyceride in adipose tissue as a result of its stimulating action on the lipogenic pathway.
公益社団法人日本薬学会の論文
1984-11-25