Studies on the Mechanism of the Hypoglycemic Activity of Ginsenoside-Rb_2 in Streptozotocin-Diabetic Rats
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概要
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The effect of ginsenoside-Rb_2 purified from ginseng was examined in streptozotocin-induced diabetic rats. The rats of the ginsenoside-Rb_2-treated group showed a significant decrease of blood glucose level. A moderate (but statistically insignificant) increase in the hepatic glycogen content was observed. Furthermore, the ginsenoside-Rb_2-treated group showed a significant rise of glucokinase activity in the liver, while there was a significant decrease in the activity of glucose-6-phosphatase. These results suggest that the changes of glucokinase and glucose-6-phosphatase levels probably represent one of the mechanisms of the hypoglycemic action produced by ginsenoside-Rb_2.
- 公益社団法人日本薬学会の論文
- 1985-02-25
著者
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横澤 隆子
Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceut
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大浦 彦吉
Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceut
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川島 祐次
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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川島 祐次
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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小林 妙子
Department Of Applied Biochemistry Research Institute For Wakan-yaku Toyama Medical And Pharmaceutic
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