Hyperlipemia-Improving Effects of Ginsenoside-Rb_2 in Streptozotocin-Diabetic Rats
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概要
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The effect of ginsenoside-Rb_2 purified from ginseng was investigated in streptozotocin-induced diabetic rats. The rats treated with ginsenoside-Rb_2 showed significant decreases in triglyceride, non-esterified fatty acid, and total cholesterol in the serum. A lipid-improving action in the serum was observed in rats with hyperlipemia. Furthermore, the lipolytic activity of lipoprotein lipase was stimulated with a concomitant decrease in the levels of triglyceride and very low density lipoprotein in the serum, while a repressive effect on hormone-sensitive lipase activity was observed. The accumulation of lipid in the adipose tissue was also observed. In addition to the hypolipemic effect, ginsenoside-Rb_2 exhibited a lowering action on the serum levels of 3-hydroxybutyrate and acetoacetate in streptozotocin-induced diabetic rats, indicating an improvement of diabetic ketoacidosis.
- 公益社団法人日本薬学会の論文
- 1985-09-25
著者
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横澤 隆子
Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceut
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大浦 彦吉
Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceut
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川島 祐次
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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川島 祐次
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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小林 妙子
Department Of Applied Biochemistry Research Institute For Wakan-yaku Toyama Medical And Pharmaceutic
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