Effect of Serial Administration of Ginsenoside-Rb_2 in Diabetic Rats : In Terms of Carbohydrate and Lipid Metabolites(Biological,Chemical)

概要

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In order to study the mechanism of hypoglycemic action of ginsenoside-Rb_2 in diabetic rats, experiments were performed to determine carbohydrate metabolites and the levels of lipid constituents. The rats treated with ginsenoside-Rb_2 showed a significant decrease of glucose in the hepatic tissue. The level of hepatic glycogen was slightly increased after ginsenoside-Rb_2 administration. The glucose-6-phosphate level tended to increase, the pyruvate level was unchanged, and the lactate level tended to decrease. There was, however, no accumulation of total lipid in hepatic tissue. In rats given ginsenoside-Rb_2, the levels of triglyceride, non-esterified fatty acid, 3-hydroxybutyrate, and acetoacetate were markedly decreased, showing a trend toward restoration of the normal state and inducing an increase in lipids in the adipose tissue. The hypoglycemic action of einsenoside-Rb_2 is discussed on the basis of the present results.
公益社団法人日本薬学会の論文
1987-12-25