Hyperlipemia-Improving Effects of Ginsenoside-Rb_2 in cholesterol-Fed Rats
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概要
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The effect of ginsenoside-Rb_2 purified from ginseng on lipid metabolism was examined in rats fed on a high cholesterol diet. A single intraperitoneal administration of ginsenoside-Rb_2 produced a significant decrease of total cholesterol, free cholesterol, low density lipoprotein (LDL)-cholesterol, triglyceride, 3-hydroxybutyrate, and acetoacetate levels in the serum. However, a significant increase of high density lipoprotein (HDL)-cholesterol level in the serum was observed after the treatment. Repeated administration of ginsenoside-Rb_2 to rats with hyperlipemia induced by a high-cholesterol diet resulted in a striking decrease in the levels of total cholesterol, free cholesterol, LDL-cholesterol, and triglyceride, whereas the level of HDL-cholesterol was again increased. The changes were larger than those produced by a single intraperitoneal administration. Furthermore, the lipolytic activity of lipoprotein lipase was stimulated with a concomitant decrease in the levels of triglyceride and very low density lipoprotein (VLDL)-triglyceride in the serum. Accumulation of lipid in the adipose tissue was observed. In addition, a slight decrease in hepatic total cholesterol was observed after the treatment, but there was no statistically significant difference between the control and ginsenoside-Rb_2-treated groups. The mechanism of hypolipemic action of ginsenoside-Rb_2 is discussed on the basis of these results.
- 公益社団法人日本薬学会の論文
- 1985-02-25
著者
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横澤 隆子
Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceut
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大浦 彦吉
Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceut
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川島 祐次
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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小林 妙子
Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceut
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川合 晶子
Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceut
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川合 晶子
Department Of Applied Biochemistry Research Institute For Wakan-yaku Toyama Medical And Pharmaceutic
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川島 祐次
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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小林 妙子
Department Of Applied Biochemistry Research Institute For Wakan-yaku Toyama Medical And Pharmaceutic
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