Evaluation of Corticosterone Secretion-inducing Activities of Ginsenosides and Their Prosapogenins and Sapogenins

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Ginsenosides Rb_1,Rb_2,Rc, Rd, Re and Rg_1 (GRb_1,GRb_2 and so on) isolated from the roots of Panax ginseng C.A. MEYER, and their 20S- and 20R-prosapogenins (S-PS and R-PS), 20S- and 20R-protopanaxadiols (S-PPD and R-PPD), and a mixture of 20S- and 20R-panaxadiols (SR-PD) at various doses were administered to rats intraperitoneally. Plasma corticosterone and glucose levels at 30 min after the administration were determined, and ED_<50> values for corticosterone level were estimated. The ED_<50> values of GRd, GRb_2,GRc and GRb_1 were 7.1,20,44 and 112μmol/kg, respectively. ED_<50> of S-PS, the genuine prosapogenin of GRb_1,GRb_2,GRc and GRd, which has no sugar residue attached to the C-20 position, was 28μmol/kg, and the artifact prosapogenin R-PS also showed nearly the same activity, 26μmol/kg. The ED_<50> values of genuine and artifact sapogenins S- and R-PPD were 42 and 32μmol/kg, respectively, but an epimeric mixture of two artifact sapogenins SR-PD showed no activity at a dose of 80μmol/kg. The ED_<50> values of GRe and GRg_1,glycosides of 20S-protopanaxatriol, were 107 and >160μmol/kg, respectively. Most of these 11 compounds did not significantly affect the plasma glucose level at 30 min after the treatment.
社団法人日本薬学会の論文
1983-01-25