Effect of Saikosaponins on Dexamethasone Suppression of the Pituitary-Adrenocortical System
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概要
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The effect of saikosaponins d and a on corticosterone secretion was investigated in dexamethasone-treated rats (250μg/kg, 0.64×10^<-6>mol/kg, i.p. 3h before saponin injection). Plasma corticosterone level 30min after saponin injection was determined by the competitive protein binding method. Saikosaponins d and a both had no effect at low doses, but elevated plasma corticosterone levels at higher doses. ED_<50> values for corticosterone response to saikosaponins d and a were 1.4mg/kg (1.8×10^<-6>mol/kg) and 3.8mg/kg (4.9×10^<-6>mol/kg) in the dexamethasone-treated rats, and these values were 4.2 and 4.3 times greater than the ED_<50> values determined in rats without dexamethasone treatment, respectively.
- 社団法人日本薬学会の論文
- 1984-03-25
著者
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日合 奨
富山医科薬科大学和漢薬研究所
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大浦 彦吉
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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日合 奨
Research Institute for Wakan-Yaku(Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceu
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横山 弘臣
Research Institute for WAKAN-YAKU, Toyama Medical and Pharmaceutical University
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横山 弘臣
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
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