Effect of Chronic Treatment with Saikosaponin d and Dexamethasone on Responsiveness of Pituitary and Adrenal Cortex and Adrenal Weight in Rats(Biological)

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Basal and maximum corticosterone secretions of the whole pituitary-adrenal cortex system or the adrenal cortex were determined in rats treated with saikosaponin d(saiko-d) from Bupleurwnfalcaium L. alone or with dexamethasone for 5 or 9d. In rats treated with 0.5,1.0 or 2.5 mg/kg/d of saiko-d, or saiko-d and 0.025 mg/kg/d of dexamethasone for 5d, both basal and acutely stimulated evening levels of plasma corticosterone on day 5 were very slightly below normal; the stimulated level due to saiko-d was significantly higher than the basal level, but was not significantly lower than the normal and adrenocorticotropin (ACTH)-stimulated maximum level. In rats chronically treated with saiko-d(2.5 mg/kg/d) alone, or with saiko-d and a high dose of dexamethasone(0.05 mg/kg/d) for 9 d, the stimulated level of corticosterone was nearly equal to the basal level, and saiko-d administered with dexamethasone reduced the adrenal weight on day 9. These chronic effects of saiko-d on the adrenal activity and weight were fully effective in the early phase, but were less effective and then suppressive in the late phase, especially at a high dose of saiko-d or on coadministration of saiko-d and dexamethasone.
社団法人日本薬学会の論文
1987-07-25