桔梗総サポニンならびにそのProsapogenin Methyl Estersのラット血漿コルチコステロン分泌促進活性

概要

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Effects of total saponin from the roots of Platycodon grandiflorum A.DC. and its prosapogenin methyl esters on rat plasma corticosterone level were examined by competitive protein binding method. Total saponin and prosapogenin methyl esters were administered intraperitoneally to rat acclimatized by handling and the rat was sacrificed 30 min thereafter. Total saponin (1 mg/kg or more) elevated plasma corticosterone to the maximal level (about 40μg/100 ml). Plasma adrenocorticotropin (ACTH) was shown to increase significantly at 5 mg/kg of total saponin. Plasma glucose increased significantly at doses of 5 mg/kg or more of total saponin, but not of 1 mg/kg. 3-O-β-D-Glucopyranosyl- and 3-O-β-laminaribiosyl-platycodigenin methyl esters, and 3-O-β-D-glucopyranosyl-and 3-O-β-laminaribiosyl-polygalacic acid methyl esters increased plasma corticosterone maximally at 2μmol/kg (1.4-1.8 mg/kg) of doses. These results showed that the stimulating action on the pituitary-adrenocortical axis might be due to platycodigenin- or polygalacic acid-containing total saponin preparation of Platycoden grandiflorum A.DC.
社団法人日本薬学会の論文
1982-12-25