SYNTHESIS OF THE B/C-RING SYSTEM OF TETRONASIN (ICI-139603)

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概要

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• An efficient entry to the tetrahydropyran/cyclohexane moiety of tetronasin has been developed. An aldol reaction between a cyclohexanecarboxaldehyde, 8,and a (tetrahydropyranyl)acetate, 9,under controlled conditions followed by dehydration of the adduct 10 afforded predominantly (E)-ester 11,which on photoisomerization and subsequent reduction with iso-Bu_2AlH provided the B/C ring system 13.

• 公益社団法人日本薬学会の論文
• 1990-06-25

著者

• 野村 敬一

  Faculty of Pharmaceutical Sciences, Toyama Medical Pharmaceutical University

• 野村 敬一

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 吉井 英一

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 吉井 英一

  富山医科薬科大学薬学部

• 稲垣 敦士

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 堀 耕造

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 森 秋穂

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 森 秋穂

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 堀 耕造

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

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